Gene
ppox
- ID
- ZDB-GENE-051120-90
- Name
- protoporphyrinogen oxidase
- Symbol
- ppox Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable oxygen-dependent protoporphyrinogen oxidase activity. Predicted to be involved in heme biosynthetic process. Predicted to act upstream of or within porphyrin-containing compound biosynthetic process. Predicted to be active in mitochondrial inner membrane. Is expressed in blood cell; intermediate cell mass of mesoderm; and lateral plate mesoderm. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Dooley et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| variegate porphyria | Alliance | Variegate porphyria | 176200 |
| Variegate porphyria, childhood-onset | 620483 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| variegate porphyria | ppoxt23572/t23572 (TU) | standard conditions | Dooley et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Protoporphyrinogen oxidase | Zeta Carotene Desaturase and Related Oxidoreductases |
|---|---|---|---|---|---|
|
UniProtKB:Q32LU4
|
477 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available