Gene
kcnk2b
- ID
- ZDB-GENE-051120-69
- Name
- potassium channel, subfamily K, member 2b
- Symbol
- kcnk2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables mechanosensitive monoatomic ion channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; female organism; and male organism. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Potassium channel domain | Two pore domain potassium channel | Two pore domain potassium channel, TREK |
|---|---|---|---|---|---|
| UniProtKB:Q32LX0 | InterPro | 384 | |||
| UniProtKB:A0AB32TCH9 | InterPro | 425 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk2b-201
(1)
|
Ensembl | 1,470 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-121J17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123268 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037398 (1) | 1632 nt | ||
| Genomic | GenBank:BX855610 (2) | 139210 nt | ||
| Polypeptide | UniProtKB:A0AB32TCH9 (1) | 425 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Loganathan, K., Moriya, S., Parhar, I.S. (2019) Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Zoological science. 36:167-171
- Loganathan, K., Moriya, S., Parhar, I.S. (2018) High Melatonin Conditions by Constant Darkness and High Temperature Differently Affect Melatonin Receptor mt1 and TREK Channel trek2a in the Brain of Zebrafish. Zebrafish. 15(5):473-483
- Luo, J.J., Su, D.S., Xie, S.L., Liu, Y., Liu, P., Yang, X.J., Pei, D.S. (2018) Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5):2814-2826
- Nasr, N., Faucherre, A., Borsotto, M., Heurteaux, C., Mazella, J., Jopling, C., Moha Ou Maati, H. (2018) Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b. Scientific Reports. 8:15311
- Loganathan, K., Moriya, S., Sivalingam, M., Ng, K.W., Parhar, I.S. (2017) Sequence and Localization of kcnk10a in the Brain of Adult Zebrafish (Danio rerio). Journal of chemical neuroanatomy. 86:92-99
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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