Gene

pfkfb4a

ID
ZDB-GENE-051120-51
Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
Symbol
pfkfb4a Nomenclature History
Previous Names
  • pfkfb4
  • zgc:123288
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zhou et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa27815Allele with one point mutationUnknownSplice SiteENU
sa27816Allele with one point mutationUnknownSplice SiteENU
sa35129Allele with one point mutationUnknownSplice SiteENU
1 - 3 of 3
Show
Sequence Targeting Reagents
No data available
Human Disease
Associated With pfkfb4a Human Ortholog
No data available
Associated With pfkfb4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain IPR013079 6-phosphofructo-2-kinase
Family IPR003094 Fructose-2,6-bisphosphatase
Family IPR013078 Histidine phosphatase superfamily, clade-1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase Histidine phosphatase superfamily Histidine phosphatase superfamily, clade-1 Phosphoglycerate/bisphosphoglycerate mutase, active site P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q32LS8 InterPro 482
UniProtKB:A0AB13AB36 InterPro 453
UniProtKB:A0A8M1N836 InterPro 482
UniProtKB:A0AB32TZB1 InterPro 482
UniProtKB:A0AB32U047 InterPro 453
1 - 5 of 5
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pfkfb4a-201 (1) Ensembl 1,977 nt
mRNA pfkfb4a-202 (1) Ensembl 1,452 nt
mRNA pfkfb4a-203 (1) Ensembl 1,524 nt
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-25G11ZFIN Curated Data
EncodescDNAMGC:123288ZFIN Curated Data
1 - 2 of 2
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPFKFB43
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MousePfkfb49
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 7 of 7
Show