Gene
pfkfb4a
- ID
- ZDB-GENE-051120-51
- Name
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
- Symbol
- pfkfb4a Nomenclature History
- Previous Names
-
- pfkfb4
- zgc:123288
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhou et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001345 | Phosphoglycerate/bisphosphoglycerate mutase, active site |
| Domain | IPR013079 | 6-phosphofructo-2-kinase |
| Family | IPR003094 | Fructose-2,6-bisphosphatase |
| Family | IPR013078 | Histidine phosphatase superfamily, clade-1 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029033 | Histidine phosphatase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 6-phosphofructo-2-kinase | Fructose-2,6-bisphosphatase | Histidine phosphatase superfamily | Histidine phosphatase superfamily, clade-1 | Phosphoglycerate/bisphosphoglycerate mutase, active site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q32LS8 | InterPro | 482 | ||||||
| UniProtKB:A0AB13AB36 | InterPro | 453 | ||||||
| UniProtKB:A0A8M1N836 | InterPro | 482 | ||||||
| UniProtKB:A0AB32TZB1 | InterPro | 482 | ||||||
| UniProtKB:A0AB32U047 | InterPro | 453 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pfkfb4a-201
(1)
|
Ensembl | 1,977 nt | ||
| mRNA |
pfkfb4a-202
(1)
|
Ensembl | 1,452 nt | ||
| mRNA |
pfkfb4a-203
(1)
|
Ensembl | 1,524 nt |
Interactions and Pathways
No data available
Plasmids
No data available