Gene
mapk10
- ID
- ZDB-GENE-051120-117
- Name
- mitogen-activated protein kinase 10
- Symbol
- mapk10 Nomenclature History
- Previous Names
-
- jnk3 (1)
- zgc:123234
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable JUN kinase activity. Acts upstream of or within enteric nervous system development and liver development. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; enteric nervous system; eye; and heart. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human MAPK10 (mitogen-activated protein kinase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fci200 | Allele with one deletion | Exon 4 | Frameshift | TALEN | |
| la014121Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| n5 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa23859 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mapk10 | Derrick et al., 2022 | |
| MO1-mapk10 | N/A | Liu et al., 2013 |
| MO2-mapk10 | N/A | Liu et al., 2013 |
| MO3-mapk10 | N/A | Heanue et al., 2016 |
| TALEN1-mapk10 | Heanue et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR008351 | Mitogen-activated protein (MAP) kinase, JNK |
| Family | IPR050117 | Mitogen-activated protein kinase |
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Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Mitogen-activated protein (MAP) kinase, JNK | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P3E5
|
441 | ||||||
|
UniProtKB:A0A8M2B8D5
|
475 | ||||||
|
UniProtKB:A4QP40
|
384 | ||||||
|
UniProtKB:A0A8M3AWM8
|
475 | ||||||
|
UniProtKB:A0A8M9PCS4
|
425 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapk10-201
(1)
|
Ensembl | 1,887 nt | ||
| mRNA |
mapk10-202
(1)
|
Ensembl | 1,419 nt | ||
| mRNA |
mapk10-203
(1)
|
Ensembl | 1,756 nt | ||
| mRNA |
mapk10-204
(1)
|
Ensembl | 1,779 nt | ||
| mRNA |
mapk10-206
(1)
|
Ensembl | 1,863 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-65I12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-233O14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123234 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162841 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001318321 (1) | 2053 nt | ||
| Genomic | GenBank:CR354555 (2) | 177811 nt | ||
| Polypeptide | UniProtKB:A0A8M1P270 (1) | 486 aa |
- Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
- Deng, Z., Hou, K., Valencak, T.G., Luo, X.M., Liu, J., Wang, H. (2022) AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish. Microbiology spectrum. 10(4):e0061022
- Derrick, C.J., Santos-Ledo, A., Eley, L., Henderson, D.J., Chaudhry, B. (2022) Sequential action of jnk genes establishes the embryonic left-right axis. Development (Cambridge, England). 149(9):
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Gong, L., Zhou, H., Wang, C., He, L., Guo, C., Peng, C., Li, Y. (2021) Hepatoprotective effect of Forsythiaside A against acetaminophen-induced liver injury in zebrafish: coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 271:113890
- Gong, L., Yu, L., Gong, X., Wang, C., Hu, N., Dai, X., Peng, C., Li, Y. (2020) Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses. Journal of neuroinflammation. 17:173
- Lu, Z., Cao, H., Liu, D., Zheng, Y., Tian, C., Liu, S., Quan, J., Shi, L., Liu, J., Yu, L. (2020) Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Journal of ethnopharmacology. 269:113747
- Santos-Ledo, A., Washer, S., Dhanaseelan, T., Eley, L., Alqatani, A., Chrystal, P.W., Papoutsi, T., Henderson, D.J., Chaudhry, B. (2020) Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression. PLoS Genetics. 16:e1008782
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
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