Gene
camk2a
- ID
- ZDB-GENE-051113-72
- Name
- calcium/calmodulin-dependent protein kinase II alpha
- Symbol
- camk2a Nomenclature History
- Previous Names
-
- camk2a1 (1)
- zgc:112538
- zgc:123320
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables calcium/calmodulin-dependent protein kinase activity. Acts upstream of or within heart jogging and protein autophosphorylation. Predicted to be active in cytoplasm; neuron projection; and postsynaptic density. Is expressed in brain; heart; somite; and tail bud. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112538 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 53 | Alliance | Intellectual developmental disorder, autosomal dominant 53 | 617798 |
| autosomal recessive intellectual developmental disorder 63 | Alliance | ?Intellectual developmental disorder, autosomal recessive 63 | 618095 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013543 | Calcium/calmodulin-dependent protein kinase II, association-domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR032710 | NTF2-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Calcium/calmodulin-dependent protein kinase II, association-domain | NTF2-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q32PV2
|
478 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk2a-201
(1)
|
Ensembl | 1,976 nt | ||
| mRNA |
camk2a-202
(1)
|
Ensembl | 881 nt |
Interactions and Pathways
No data available
Plasmids
No data available