Gene

tcf3b

ID
ZDB-GENE-051113-64
Name
transcription factor 3b
Symbol
tcf3b Nomenclature History
Previous Names
  • tcf3a (1)
  • zgc:113045
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Agammaglobulinemia 8A, autosomal dominant 616941
Agammaglobulinemia 8B, autosomal recessive 619824
Associated With tcf3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:B1H1L4 652
UniProtKB:A0A8M2BHT8 634
UniProtKB:A0A8M3AMB2 651
UniProtKB:A0A8M3B5J8 627
UniProtKB:A0A0R4IMI6 635
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations