Gene
aplnrb
- ID
- ZDB-GENE-050913-90
- Name
- apelin receptor b
- Symbol
- aplnrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables apelin receptor activity. Involved in cardiac muscle tissue development; cell migration; and gastrulation with mouth forming second. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within several processes, including blood vessel morphogenesis; endodermal cell differentiation; and mesodermal cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including angioblastic mesenchymal cell; blastodisc; cardiovascular system; mesoderm; and pleuroperitoneal region. Orthologous to human APLNR (apelin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a170 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hu4145 | Allele with one point mutation | Unknown | Unknown | not specified | |
| la017638Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mu270 | Allele with one insertion | Exon 1 | Premature Stop | CRISPR | |
| mu281 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| s608 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aplnrb | (4) | |
| CRISPR2-aplnrb | (2) | |
| CRISPR3-aplnrb | Norris et al., 2017 | |
| MO1-aplnrb | N/A | (8) |
| MO2-aplnrb | N/A | (2) |
| MO3-aplnrb | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Angiotensin II receptor family | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:A0T2N3 | InterPro | 359 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aplnrb-201
(1)
|
Ensembl | 2,087 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(aplnrb:aplnrb-TagRFP-sfGFP) |
|
| 1 | Helker et al., 2020 | |
| TgBAC(aplnrb:Venus) |
|
| 1 | Qi et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-111A5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114063 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030197 (1) | 2114 nt | ||
| Genomic | GenBank:CU655827 (2) | 39747 nt | ||
| Polypeptide | UniProtKB:A0T2N3 (1) | 359 aa |
- Nys, N., Khatib, A.M., Siegfried, G. (2024) Apela promotes blood vessel regeneration and remodeling in zebrafish. Scientific Reports. 14:37183718
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
- Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:
- Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
- Ashokan, A., Kameswaran, M., Aradhyam, G.K. (2019) Molecular determinants on extracellular loop domains that dictate interaction between β-arrestin and human APJ receptor. FEBS letters. 593:634-643
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