Gene

fbxo6.2

ID

ZDB-GENE-050913-78

Name

F-box protein 6, tandem duplicate 2

Symbol

fbxo6.2 Nomenclature History

Previous Names

fbxo44.4
zgc:114081

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to localize to SCF ubiquitin ligase complex and cytoplasm. Orthologous to human FBXO44 (F-box protein 44) and FBXO6 (F-box protein 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:114081 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fbxo6.2 Human Ortholog

No data available

Associated With fbxo6.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Domain	IPR007397	F-box associated (FBA) domain
Family	IPR039752	F-box only protein
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036047	F-box-like domain superfamily

Domain Details Per Protein

Protein	Length	F-box associated (FBA) domain	F-box domain	F-box-like domain superfamily	F-box only protein	Galactose-binding-like domain superfamily
UniProtKB:A0A8M2B992 InterPro	247
UniProtKB:Q4V8Y9 InterPro	211
UniProtKB:A0A8M9PKT0 InterPro	273

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zgc:114081-201 (1) Ensembl	Ensembl	1,467 nt	Select Tool ZFIN BLAST
mRNA	zgc:114081-202 (1) Ensembl	Ensembl	829 nt	Select Tool
mRNA	zgc:114081-203 (1) Ensembl	Ensembl	1,505 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: This gene is in a cluster of ten fbxo6/fbxo44 genes and relationships are difficult to discern. Current analysis (January 2021) suggests three fbxo44 and fbxo6 gene pairs followed by four additional fbxo44 genes.

Citations