Gene

c1r

ID

ZDB-GENE-050913-24

Name

complement component 1, r subcomponent

Symbol

c1r Nomenclature History

Previous Names

zgc:112309

Type

protein_coding_gene

Location

Unmapped

Description

Predicted to have serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to localize to blood microparticle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Orthologous to human C1R (complement C1r).

Genome Resources

Note

None

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c1r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Ehlers-Danlos syndrome, periodontal type, 1	130080

Associated With c1r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR000742	EGF-like domain
Domain	IPR000859	CUB domain
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR001881	EGF-like calcium-binding domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR035707	Complement C1r subcomponent
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Complement C1r subcomponent	CUB domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Peptidase S1A, chymotrypsin family	Peptidase S1, PA clan	Peptidase S1, PA clan, chymotrypsin-like fold	Serine proteases, trypsin domain	Serine proteases, trypsin family, serine active site	Spermadhesin, CUB domain superfamily	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:Q4V9I1 InterPro	195
UniProtKB:A0A0R4IL35 InterPro	662

Transcripts

Genome Browsers: No data available

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations