Gene

c1r

ID
ZDB-GENE-050913-24
Name
complement component 1, r subcomponent
Symbol
c1r Nomenclature History
Previous Names
  • zgc:112309
Type
protein_coding_gene
Location
Unmapped
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to localize to blood microparticle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Orthologous to human C1R (complement C1r).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c1r Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ehlers-Danlos syndrome, periodontal type, 1 130080
Associated With c1r Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR035707 Complement C1r subcomponent
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Complement C1r subcomponent CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, serine active site Spermadhesin, CUB domain superfamily Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily
UniProtKB:Q4V9I1 195
UniProtKB:A0A0R4IL35 662
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations