Gene
comta
- ID
- ZDB-GENE-050913-117
- Name
- catechol-O-methyltransferase a
- Symbol
- comta Nomenclature History
- Previous Names
-
- zgc:114157 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to act upstream of or within catecholamine metabolic process and methylation. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; male organism; nervous system; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| panic disorder | Alliance | {Panic disorder, susceptibility to} | 167870 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Catechol O-methyltransferase, eukaryotic | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|
| UniProtKB:F4ZGF2 | InterPro | 256 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myo6b:comta-EGFP) |
|
| 1 | Erickson et al., 2017 | |
| Tg(myo6b:comta-emGFP) |
|
| 1 | Erickson et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114157 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030157 (1) | 771 nt | ||
| Genomic | GenBank:CR457452 (1) | 232104 nt | ||
| Polypeptide | UniProtKB:F4ZGF2 (1) | 256 aa |
- Campbell, P.D., Lee, I., Thyme, S., Granato, M. (2023) Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Molecular psychiatry. 28(9):3769-3781
- Simonian, R., Pannia, E., Hammoud, R., Noche, R.R., Cui, X., Kranenburg, E., Kubant, R., Ashcraft, P., Wasek, B., Bottiglieri, T., Dowling, J.J., Anderson, G.H. (2023) Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Human molecular genetics. 32(9):1575-1588
- Yang, R., Zhang, Y., Deng, Y., Yang, Y., Zhong, W., Zhu, L. (2023) 2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2. Environmental science & technology. 57(38):14162-14172
- Baronio, D., Chen, Y.C., Decker, A.R., Enckell, L., Fernández-López, B., Semenova, S., Puttonen, H.A.J., Cornell, R.A., Panula, P. (2021) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta physiologica (Oxford, England). 234(1):e13725
- Faria, M., Bedrossiantz, J., Ramírez, J.R.R., Mayol, M., García, G.H., Bellot, M., Prats, E., Garcia-Reyero, N., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2020) Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety. Environment International. 146:106253
- Liu, S., Yu, M., Xie, X., Ru, Y., Ru, S. (2020) Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. 253:126635
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Chen, H., Feng, W., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Ding, Y., Wu, X. (2019) Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary. Aquatic toxicology (Amsterdam, Netherlands). 216:105290
- Yuan, L., Qian, L., Qian, Y., Liu, J., Yang, K., Huang, Y., Wang, C., Li, Y., Mu, X. (2019) Bisphenol F-induced neurotoxicity towards zebrafish embryos. Environmental science & technology. 53(24):14638-14648
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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