Gene
agxt2
- ID
- ZDB-GENE-050913-100
- Name
- alanine--glyoxylate aminotransferase 2
- Symbol
- agxt2 Nomenclature History
- Previous Names
-
- im:7153274
- zgc:114195
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable alanine-glyoxylate transaminase activity. Predicted to be involved in L-alanine catabolic process, by transamination and glyoxylate catabolic process. Predicted to be active in mitochondrion. Is expressed in liver; notochord; pronephric duct; and pronephros. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153274 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Beta-aminoisobutyric acid, urinary excretion of] | 210100 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR049704 | Aminotransferases class-III pyridoxal-phosphate attachment site |
| Family | IPR005814 | Aminotransferase class-III |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase class-III | Aminotransferases class-III pyridoxal-phosphate attachment site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4V8R2 | InterPro | 517 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available