Gene
sult1st5
- ID
- ZDB-GENE-050809-2
- Name
- sulfotransferase family 1, cytosolic sulfotransferase 5
- Symbol
- sult1st5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables sulfotransferase activity. Acts upstream of or within xenobiotic metabolic process. Predicted to be active in cytoplasm. Orthologous to several human genes including SULT1C2 (sulfotransferase family 1C member 2) and SULT1C4 (sulfotransferase family 1C member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yasuda et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43982 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|
| UniProtKB:Q49IK6 | InterPro | 293 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sult1st5-201
(1)
|
Ensembl | 1,029 nt | ||
| mRNA |
sult1st5-202
(1)
|
Ensembl | 810 nt | ||
| ncRNA |
sult1st5-003
(1)
|
Ensembl | 803 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31B16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199903 (1) | 1046 nt | ||
| Genomic | GenBank:BX957326 (1) | 259092 nt | ||
| Polypeptide | UniProtKB:Q49IK6 (1) | 293 aa |
No data available
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Kim, J., Lee, G., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line. Chemosphere. 262:128012
- Liang, Y.Q., Xu, W., Liang, X., Jing, Z., Pan, C.G., Tian, F. (2020) The synthetic progestin norethindrone causes thyroid endocrine disruption in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 236:108819
- Hamid, N., Junaid, M., Pei, D.S. (2019) Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of hazardous materials. 382:121106
- Junaid, M., Wang, Y., Hamid, N., Deng, S., Li, W.G., Pei, D.S. (2019) Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. Journal of hazardous materials. 380:120828
- Wang, J., Shi, G., Yao, J., Sheng, N., Cui, R., Su, Z., Guo, Y., Dai, J. (2019) Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption. Environment International. 134:105317
- Yamauchi, K., Katsumata, S., Ozaki, M. (2019) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Genes & genetic systems. 94(5):207-217
- Liu, Y., Junaid, M., Wang, Y., Tang, Y.M., Bian, W.P., Xiong, W.X., Huang, H.Y., Chen, C.D., Pei, D.S. (2018) New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquatic toxicology (Amsterdam, Netherlands). 201:151-161
- Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced cyp1a mRNA in zebrafish larvae.. Toxicology reports. 4:614-624
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