Gene

dpysl4

ID

ZDB-GENE-050720-3

Name

dihydropyrimidinase like 4

Symbol

dpysl4 Nomenclature History

Previous Names

CRMP-3 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to act upstream of or within neuron death and neuron projection guidance. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in nervous system; spinal cord neural tube; and trigeminal placode. Orthologous to human DPYSL4 (dihydropyrimidinase like 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Schweitzer et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dpysl4 Human Ortholog

No data available

Associated With dpysl4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006680	Amidohydrolase-related
Family	IPR011778	Hydantoinase/dihydropyrimidinase
Family	IPR050378	Metallo-dependent Hydrolases Superfamily
Homologous_superfamily	IPR011059	Metal-dependent hydrolase, composite domain superfamily
Homologous_superfamily	IPR032466	Metal-dependent hydrolase

Domain Details Per Protein

Protein	Length	Amidohydrolase-related	Hydantoinase/dihydropyrimidinase	Metal-dependent hydrolase	Metal-dependent hydrolase, composite domain superfamily	Metallo-dependent Hydrolases Superfamily
UniProtKB:A0A0R4IYX8 InterPro	574
UniProtKB:A0A8M9Q8F2 InterPro	675
UniProtKB:Q52PJ4 InterPro	555

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dpysl4-201 (1) Ensembl	Ensembl		1,093 nt	Select Tool ZFIN BLAST
mRNA	dpysl4-202 (1) Ensembl	Ensembl		2,170 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations