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ZIRC
ZFIN ID: ZDB-GENE-050628-1
Gene Name: mindbomb E3 ubiquitin protein ligase 2
Gene Symbol: mib2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Unmapped
Description: Exhibits protein homodimerization activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including melanocyte differentiation; protein autoubiquitination; and regulation of receptor internalization. Localizes to the cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in inner ear; mesenchyme pectoral fin; and pectoral fin. Orthologous to human MIB2 (mindbomb E3 ubiquitin protein ligase 2).
Genome Resources: Alliance (1),  Gene:560887 (1),  Ensembl(GRCz11):ENSDARG00000103609 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
chi1 Small Deletion Exon 6 Premature Stop TALEN
chi2 Complex Unknown Premature Stop TALEN
chi3 Small Deletion Unknown Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mib2 N/A 1
MO2-mib2 N/A 1
MO3-mib2 N/A 1
MO4-mib2 N/A 1
TALEN1-mib2 1
PHENOTYPE
Data: Fig. 2 from Mikami et al., 2015
Observed in:
DISEASE ASSOCIATED WITH mib2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mib2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein autoubiquitination (more)
Cellular Component cytoplasm (more)
Molecular Function CONTRIBUTES_TO   ubiquitin-protein transferase activity (more)
GO Terms (all 14)
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mib2 No data available
MARKER RELATIONSHIPS
mib2 Encodes: [cDNA] MGC:194322 (1) (order this), MGC:194323 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001079678 (1)
Genomic GenBank:CABZ01090210 (1) 11563 bp
Polypeptide UniProtKB:A0AR23 (1) 999 aa
Sequence Clusters UniGene:104375 (1)
Sequence Information (all 25)
ORTHOLOGY for mib2 ( Unmapped )
CITATIONS (18)