Gene

mib2

ID
ZDB-GENE-050628-1
Name
MIB E3 ubiquitin protein ligase 2
Symbol
mib2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including melanocyte differentiation; protein autoubiquitination; and regulation of receptor internalization. Localizes to cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in inner ear; mesenchyme pectoral fin; and pectoral fin. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Mikami et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mib2 Human Ortholog
No data available
Associated With mib2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR001841 Zinc finger, RING-type
Domain IPR010606 Mib-herc2
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR040847 Mind bomb, SH3 repeat domain
Domain IPR042056 E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Homologous_superfamily IPR037252 Mib/herc2 domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type Mib-herc2 Mib/herc2 domain superfamily Mind bomb, SH3 repeat domain Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:A0A0G2KXP0 889
UniProtKB:A0AR23 999
UniProtKB:B3DJW1 998
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations