Gene
tnnt2d
- ID
- ZDB-GENE-050626-97
- Name
- troponin T2d, cardiac
- Symbol
- tnnt2d Nomenclature History
- Previous Names
-
- zgc:114184
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in myotome and somite.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu989 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ferrante et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023207Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023208Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin T |
|---|---|---|---|---|---|
| UniProtKB:Q4QRC7 | InterPro | 241 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnt2d-201
(1)
|
Ensembl | 726 nt | ||
| mRNA |
tnnt2d-202
(1)
|
Ensembl | 968 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-206M15 | ZFIN Curated Data | |
| Encodes | EST | eu989 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:114184 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025179 (1) | 981 nt | ||
| Genomic | GenBank:BX928758 (1) | 90241 nt | ||
| Polypeptide | UniProtKB:Q4QRC7 (1) | 241 aa |
No data available
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. (2021) The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 259:111016
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Zou, X., Liu, Q., Guo, S., Zhu, J., Han, J., Xia, Z., Du, Y., Wei, L., Shang, J. (2019) A Novel Zebrafish Larvae Hypoxia/Reoxygenation Model for Assessing Myocardial Ischemia/Reperfusion Injury. Zebrafish. 16(5):434-442
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Xu, Q.H., Guan, P., Zhang, T., Lu, C., Li, G., Liu, J.X. (2018) Silver nanoparticles impair zebrafish skeletal and cardiac myofibrillogenesis and sarcomere formation. Aquatic toxicology (Amsterdam, Netherlands). 200:102-113
- Zhang, L., Yang, Y., Li, B., Scott, I.C., Lou, X. (2018) The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development (Cambridge, England). 145(8)
- Sundarrajan, L., Yeung, C., Hahn, L., Weber, L.P., Unniappan, S. (2017) Irisin regulates cardiac physiology in zebrafish. PLoS One. 12:e0181461
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
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