Gene
gjd6
- ID
- ZDB-GENE-050616-5
- Name
- gap junction protein delta 6
- Symbol
- gjd6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables gap junction hemi-channel activity. Acts upstream of or within cardiac myofibril assembly. Located in plasma membrane. Is expressed in heart; heart primordium; margin; and primitive heart tube.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Sultana et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| jk65 | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Connexin | Connexin, conserved site | Connexin, N-terminal | Connexin, N-terminal domain superfamily | Gap junction protein, cysteine-rich domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A7VKB2
|
323 | |||||
|
UniProtKB:F6P2X6
|
362 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cx36.7-201
(1)
|
Ensembl | 1,178 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.5gjd6-Xla.Eef1a1:EGFP) |
|
| 1 | Miyagi et al., 2016 | |
| Tg(-.133gjd6-Xla.Eef1a1:EGFP) |
|
| 1 | Miyagi et al., 2016 |
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No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001103197 (1) | 1178 nt | ||
| Genomic | GenBank:CABZ01068863 (1) | 29193 nt | ||
| Polypeptide | UniProtKB:F6P2X6 (1) | 362 aa |
No data available
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Mikalsen, S.O., Tausen, M., Í Kongsstovu, S. (2020) Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. BMC Genomics. 21:223
- Usui, Y., Aramaki, T., Kondo, S., Watanabe, M. (2019) The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish. Development (Cambridge, England). 146(22):
- Miyagi, H., Nag, K., Sultana, N., Munakata, K., Hirose, S., Nakamura, N. (2016) Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression. Gene. 577(2):265-74
- Kurtenbach, S., Prochnow, N., Kurtenbach, S., Klooster, J., Zoidl, C., Dermietzel, R., Kamermans, M., and Zoidl, G. (2013) Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One. 8(10):e77722
- Vermot, J., Forouhar, A.S., Liebling, M., Wu, D., Plummer, D., Gharib, M., and Fraser, S.E. (2009) Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart. PLoS Biology. 7(11):e1000246
- Sultana, N., Nag, K., Hoshijima, K., Laird, D.W., Kawakami, A., and Hirose, S. (2008) Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proceedings of the National Academy of Sciences of the United States of America. 105(12):4763-4768
- Cruciani, V., and Mikalsen, S.O. (2007) Evolutionary selection pressure and family relationships among connexin genes. Biological chemistry. 388(3):253-264
- Eastman, S.D., Chen, T.H., Falk, M.M., Mendelson, T.C., and Iovine, M.K. (2006) Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 87(2):265-274
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