Gene
gja10a
- ID
- ZDB-GENE-050616-15
- Name
- gap junction protein alpha 10 a
- Symbol
- gja10a Nomenclature History
- Previous Names
-
- cx52.7 (1)
- zgc:194445
- zgc:194451
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Is expressed in brain; kidney; muscle; and retina. Orthologous to human GJA10 (gap junction protein alpha 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36367 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Connexin | Connexin, conserved site | Connexin, N-terminal | Connexin, N-terminal domain superfamily | Gap junction protein, cysteine-rich domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0FL75 | InterPro | 464 | |||||
| UniProtKB:B3DJY1 | InterPro | 464 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cx52.7-201
(1)
|
Ensembl | 2,038 nt | ||
| mRNA |
cx52.7-202
(1)
|
Ensembl | 1,513 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gja10a:EGFP) |
|
| 1 | Klaassen et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153J3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194445 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194451 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113502 (1) | 1395 nt | ||
| Genomic | GenBank:CT485993 (1) | 151309 nt | ||
| Polypeptide | UniProtKB:B0FL75 (1) | 464 aa |
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Mikalsen, S.O., Tausen, M., Í Kongsstovu, S. (2020) Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. BMC Genomics. 21:223
- Usui, Y., Aramaki, T., Kondo, S., Watanabe, M. (2019) The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish. Development (Cambridge, England). 146(22):
- Elliott, S.B., Harvey-Girard, E., Giassi, A.C., Maler, L. (2017) Hippocampal-like circuitry in the pallium of an electric fish: Possible substrates for recursive pattern separation and completion. The Journal of comparative neurology. 525(1):8-46
- Greb, H., Hermann, S., Dirks, P., Ommen, G., Kretschmer, V., Schultz, K., Zoidl, G., Weiler, R., Janssen-Bienhold, U. (2017) Complexity of Gap Junctions between Horizontal Cells of The Carp Retina. Neuroscience. 340:8-22
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Klaassen, L.J., de Graaff, W., Van Asselt, J.B., Klooster, J., Kamermans, M. (2016) Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina. Journal of neurophysiology. 116(6):2799-2814
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
- Watanabe, M., Sawada, R., Aramaki, T., Skerrett, I.M., Kondo, S. (2016) The physiological characterization of Connexin41.8 and Connexin39.4, which are involved in the stripe pattern formation of zebrafish. The Journal of biological chemistry. 291(3):1053-63
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