Gene

lta

ID
ZDB-GENE-050601-3
Name
lymphotoxin alpha (TNF superfamily, member 1)
Symbol
lta Nomenclature History
Previous Names
  • LT-alpha (1)
  • TNF-N (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have tumor necrosis factor receptor binding activity. Involved in response to exogenous dsRNA and response to lipopolysaccharide. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human LTA (lymphotoxin alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lta Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Leprosy, susceptibility to, 4} 610988
{Myocardial infarction, susceptibility to} 608446
{Psoriatic arthritis, susceptibility to} 607507
Associated With lta Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006052 Tumour necrosis factor domain
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
Domain Details Per Protein
Protein Length Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:Q4W897 203
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations