ZFIN ID: ZDB-GENE-050525-3
Gene Name: interleukin 12Ba
Gene Symbol: il12ba    Nomenclature History

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Previous Names: il-12p40.a (1), il12b, zgc:152789

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have cytokine activity and cytokine receptor activity. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Is expressed in dendritic cell. Orthologous to human IL12B (interleukin 12B).
Genome Resources: Alliance (1),  Gene:445373 (1),  Ensembl(GRCz11):ENSDARG00000033727 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18013 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31998 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH il12ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 29, mycobacteriosis 614890
    DISEASE ASSOCIATED WITH il12ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component extracellular region (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR015528 Interleukin-12 beta
    Domain IPR019482 Interleukin-12 beta, central domain
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA il12ba-201 (1)    Ensembl 1343
    il12ba-202 (1)    Ensembl 1107
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM il12ba No data available
    MARKER RELATIONSHIPS
    il12ba Contained in: [BAC] CH73-197E12 (1), CH73-242A13 (1), CH211-128A7, DKEYP-22F6
    il12ba Encodes: [cDNA] MGC:152789 (1), MGC:191752 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007108 (1) 1343 bp
    Genomic GenBank:BX005211 191332 bp
    Select Tool
    Polypeptide UniProtKB:A8WH99 (1) 350 aa
    Sequence Information (all 23)
    ORTHOLOGY for il12ba ( Chr: 14 )
    CITATIONS (35)