Gene
inhbab
- ID
- ZDB-GENE-050525-2
- Name
- inhibin subunit beta Ab
- Symbol
- inhbab Nomenclature History
- Previous Names
-
- inhbal
- activin beta A2 (1)
- zgc:158348
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ovarian follicle. Orthologous to human INHBA (inhibin subunit beta A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR000491 | Inhibin, beta A subunit |
| Family | IPR015615 | Transforming growth factor-beta-related |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Inhibin, beta A subunit | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A1L1T8 | InterPro | 405 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
inhbab-201
(1)
|
Ensembl | 2,881 nt | ||
| mRNA |
inhbab-202
(1)
|
Ensembl | 4,118 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-12E1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158348 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001018156 (1) | 2951 nt | ||
| Genomic | GenBank:BX000484 (1) | 158932 nt | ||
| Polypeptide | UniProtKB:A1L1T8 (1) | 405 aa |
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Chen, W., Zhai, Y., Zhu, B., Wu, K., Fan, Y., Zhou, X., Liu, L., Ge, W. (2022) Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism. PLoS Genetics. 18:e1010318e1010318
- Zhao, C., Zhai, Y., Geng, R., Wu, K., Song, W., Ai, N., Ge, W. (2022) Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction. PLoS Genetics. 18:e1010523e1010523
- Weinreb, J.T., Ghazale, N., Pradhan, K., Gupta, V., Potts, K.S., Tricomi, B., Daniels, N.J., Padgett, R.A., De Oliveira, S., Verma, A., Bowman, T.V. (2021) Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Developmental Cell. 56(5):627-640.e5
- Biswas, S., Ghosh, S., Samanta, A., Das, S., Mukherjee, U., Maitra, S. (2020) Bisphenol A impairs reproductive fitness in zebrafish ovary: Potential involvement of oxidative/nitrosative stress, inflammatory and apoptotic mediators. Environmental pollution (Barking, Essex : 1987). 267:115692
- Demirci, Y., Cucun, G., Poyraz, Y.K., Mohammed, S., Heger, G., Papatheodorou, I., Ozhan, G. (2020) Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. 8:584604
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Lu, H., Zhao, C., Zhu, B., Zhang, Z., Ge, W. (2020) Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish. Endocrinology. 161(12):
- Zhang, Y., Li, M., Li, S., Wang, Q., Zhu, G., Su, G., Letcher, R.J., Liu, C. (2018) Exposure to tris(1,3-dichloro-2-propyl) phosphate for Two generations decreases fecundity of zebrafish at environmentally relevant concentrations. Aquatic toxicology (Amsterdam, Netherlands). 200:178-187
- Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
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