Gene
ism1
- ID
- ZDB-GENE-050523-3
- Name
- isthmin 1
- Symbol
- ism1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within angiogenesis; antiviral innate immune response; and hemopoiesis. Predicted to be located in extracellular region. Is expressed in several structures, including brain; forerunner cell group; germ ring; mesoderm; and pleuroperitoneal region. Orthologous to human ISM1 (isthmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ism1 | Kesavan et al., 2020 | |
| CRISPR2-ism1 | Kesavan et al., 2020 | |
| CRISPR3-ism1 | Kesavan et al., 2020 | |
| MO1-ism1 | N/A | Xiang et al., 2011 |
| MO2-ism1 | N/A | Xiang et al., 2011 |
| MO3-ism1 | N/A | Berrun et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMOP domain | Angiogenesis Inhibitor and Adhesion GPCR | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q5EGE1 | InterPro | 461 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-154C12 | ZFIN Curated Data | |
| Contains | STS | unp1086 | ||
| Encodes | cDNA | MGC:158150 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174950 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012376 (1) | 2776 nt | ||
| Genomic | GenBank:CABZ01036097 (1) | 158801 nt | ||
| Polypeptide | UniProtKB:Q5EGE1 (1) | 461 aa |
- Li, C., Zhong, S., Ni, S., Liu, Z., Zhang, S., Ji, G. (2021) Zebrafish Ism1 is a novel antiviral factor that positively regulates antiviral immune responses. Developmental and comparative immunology. 125:104210
- Kesavan, G., Raible, F., Gupta, M., Machate, A., Yilmaz, D., Brand, M. (2020) Isthmin1, a secreted signaling protein, acts downstream of diverse embryonic patterning centers in development. Cell and tissue research. 383(3):987-1002
- Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239
- Berrun, A., Harris, E., Stachura, D.L. (2018) Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish. PLoS One. 13:e0196872
- Ben-Moshe Livne, Z., Alon, S., Vallone, D., Bayleyen, Y., Tovin, A., Shainer, I., Nisembaum, L.G., Aviram, I., Smadja-Storz, S., Fuentes, M., Falcón, J., Eisenberg, E., Klein, D.C., Burgess, H.A., Foulkes, N.S., Gothilf, Y. (2016) Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. PLoS Genetics. 12:e1006445
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Satija, R., Farrell, J.A., Gennert, D., Schier, A.F., Regev, A. (2015) Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol.. 33(5):495-502
- Azuaje, F.J. (2014) Selecting biologically informative genes in co-expression networks with a centrality score. Biology Direct. 9:12
- Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
- Osório, L., Wu, X., Zhou, Z. (2014) Distinct spatiotemporal expression of ISM1 during mouse and chick development. Cell cycle (Georgetown, Tex.). 13(10):1571-82
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