Gene

nxn

ID
ZDB-GENE-050522-75
Name
nucleoredoxin
Symbol
nxn Nomenclature History
Previous Names
  • ns:zf-es94
  • zgc:110449
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway and cell differentiation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome 2. Orthologous to human NXN (nucleoredoxin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la012674TgTransgenic insertionUnknownUnknownDNA
la019168TgTransgenic insertionUnknownUnknownDNA
sa16536Allele with one point mutationUnknownPremature StopENU
sa35837Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With nxn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive Robinow syndrome 2 Alliance Robinow syndrome, autosomal recessive 2 618529
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Associated With nxn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR012336 Thioredoxin-like fold
Domain IPR013766 Thioredoxin domain
Domain IPR045870 TryX and NRX, thioredoxin domain
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Thioredoxin domain Thioredoxin-like fold Thioredoxin-like superfamily TryX and NRX, thioredoxin domain
UniProtKB:Q503L9 InterPro 418
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nxn-201 (1) Ensembl 2,478 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-259G3ZFIN Curated Data
Contained inBACDKEY-179C2ZFIN Curated Data
ContainsSNPrs3728701
    ZFIN Curated Data
    ContainsSNPrs3728702
      ZFIN Curated Data
      ContainsSNPrs3728703
        ZFIN Curated Data
        EncodesESTzf-es94Woods et al., 2005
        EncodescDNAMGC:110449ZFIN Curated Data
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        Sequences
        Orthology
        Comparative Orthology
        Alliance
        Gene Tree
        Ensembl
        Species Symbol Chromosome Accession # Evidence
        HumanNXN17
        Conserved genome location (synteny) (1)
        Amino acid sequence comparison (1)
        MouseNxn11
        Amino acid sequence comparison (1)
        Conserved genome location (synteny) (1)
        Citations