Gene

nxn

ID
ZDB-GENE-050522-75
Name
nucleoredoxin
Symbol
nxn Nomenclature History
Previous Names
  • ns:zf-es94
  • zgc:110449
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have protein-disulfide reductase activity. Predicted to be involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nxn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Robinow syndrome, autosomal recessive 2 618529
Associated With nxn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR012336 Thioredoxin-like fold
Domain IPR013766 Thioredoxin domain
Domain IPR041861 Nucleoredoxin, redox inactive TRX-like domain b'
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Nucleoredoxin, redox inactive TRX-like domain b' Thioredoxin domain Thioredoxin-like fold Thioredoxin-like superfamily
UniProtKB:A0A2R8Q546 316
UniProtKB:A0A2R8Q274 366
UniProtKB:Q503L9 418
UniProtKB:F1R5G2 418
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations