Gene

nxn

ID

ZDB-GENE-050522-75

Name

nucleoredoxin

Symbol

nxn Nomenclature History

Previous Names

ns:zf-es94
zgc:110449

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome 2. Orthologous to human NXN (nucleoredoxin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110449 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nxn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive Robinow syndrome 2	Alliance	Robinow syndrome, autosomal recessive 2	618529

Associated With nxn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012336	Thioredoxin-like fold
Domain	IPR013766	Thioredoxin domain
Domain	IPR045870	TryX and NRX, thioredoxin domain
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily