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ZIRC
ZFIN ID: ZDB-GENE-050522-534
Gene Name: growth factor independent 1A transcription repressor a
Gene Symbol: gfi1aa    Nomenclature History

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Previous Names: gfi1.1, gfi1a, zgc:113277 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in erythrocyte differentiation and primitive hemopoiesis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pancreas; and sensory system. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
Genome Resources: Alliance (1),  Gene:553814 (1),  Ensembl(GRCz11):ENSDARG00000020746 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
qmc551Gt Transgenic Insertion Intron 1 Unknown DNA
sa9056 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11633 Point Mutation Exon 4 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16850 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gfi1aa N/A 3
    MO2-gfi1aa N/A 2
    DISEASE ASSOCIATED WITH gfi1aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Neutropenia, nonimmune chronic idiopathic, of adults 607847
    ?Neutropenia, severe congenital 2, autosomal dominant 613107
    DISEASE ASSOCIATED WITH gfi1aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primitive erythrocyte differentiation (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR036236 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gfi1aa-201 (1)    Ensembl 1464
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gfi1aa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gfi1aa:GFP) gfi1aa GFP Danio rerio 1 5
    MARKER RELATIONSHIPS
    gfi1aa Contained in: [BAC] CH73-243I7 (1) (order this), DKEY-63K7 (1) (order this)
    gfi1aa Encodes: [EST] IMAGE:7158523 (1) (order this)
    [cDNA] MGC:113277 (1) (order this), MGC:192642 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020776 (1) 1480 bp
    Genomic GenBank:CR450845 (1) 232604 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1RBA7 (1) 385 aa
    Sequence Clusters UniGene:87180 (1)
    Sequence Information (all 15)
    ORTHOLOGY for gfi1aa ( Chr: 2 )
    CITATIONS (36)