Gene

gfi1aa

ID
ZDB-GENE-050522-534
Name
growth factor independent 1A transcription repressor a
Symbol
gfi1aa Nomenclature History
Previous Names
  • gfi1.1
  • gfi1a
  • zgc:113277 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in primitive erythrocyte differentiation. Predicted to localize to nucleoplasm. Is expressed in several structures, including artery; hematopoietic cell; intermediate cell mass of mesoderm; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gfi1aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
severe congenital neutropenia 2 Alliance Neutropenia, severe congenital 2, autosomal dominant 613107
?Neutropenia, nonimmune chronic idiopathic, of adults 607847
Associated With gfi1aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1RBA7 385
UniProtKB:Q501T1 385
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations