Gene
gfi1aa
- ID
- ZDB-GENE-050522-534
- Name
- growth factor independent 1A transcription repressor a
- Symbol
- gfi1aa Nomenclature History
- Previous Names
-
- gfi1.1
- gfi1a
- zgc:113277 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in primitive erythrocyte differentiation. Predicted to localize to nucleoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pancreas; and sensory system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158523 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe congenital neutropenia 2 | Alliance | Neutropenia, severe congenital 2, autosomal dominant | 613107 |
| ?Neutropenia, nonimmune chronic idiopathic, of adults | 607847 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:F1RBA7
|
385 | ||
|
UniProtKB:Q501T1
|
385 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
gfi1aa-201
(1)
|
1464 nt |
Interactions and Pathways
No data available
Plasmids
No data available