Gene

casp7

ID

ZDB-GENE-050522-506

Name

caspase 7, apoptosis-related cysteine peptidase

Symbol

casp7 Nomenclature History

Previous Names

caspase-7a (1)
zgc:110595

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activity involved in execution phase of apoptosis. Predicted to be involved in execution phase of apoptosis. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm. Is expressed in intestinal bulb; lens; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp7 Human Ortholog

No data available

Associated With casp7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR029030	Caspase-like domain superfamily