Gene

ern1

ID
ZDB-GENE-050522-431
Name
endoplasmic reticulum to nucleus signaling 1
Symbol
ern1 Nomenclature History
Previous Names
  • sb:eu1005
  • zgc:109932
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable endoribonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Acts upstream of or within response to hypoxia. Predicted to be located in membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ern1 Human Ortholog
No data available
Associated With ern1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR010513 KEN domain
Domain IPR018997 PUB domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR038357 KEN domain superfamily
Repeat IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
Domain Details Per Protein
Protein Length KEN domain KEN domain superfamily Protein kinase domain Protein kinase-like domain superfamily PUB domain Pyrrolo-quinoline quinone beta-propeller repeat Quinoprotein alcohol dehydrogenase-like superfamily Serine/threonine-protein kinase, active site WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:F1QYL2 1031
UniProtKB:Q504E3 292
UniProtKB:X1WEF9 960
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations