Gene
crygm2d1
- ID
- ZDB-GENE-050522-395
- Name
- crystallin, gamma M2d1
- Symbol
- crygm2d1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in lens and solid lens vesicle.
- Genome Resources
- Note
-
This gene was found to have embryonic specific expression.
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109890 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta/gamma crystallin | Beta/Gamma-Crystallin | Gamma-crystallin-like |
|---|---|---|---|---|---|
| UniProtKB:Q504G5 | InterPro | 174 | |||
| UniProtKB:B0S6M3 | InterPro | 175 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crygm2d1-201
(1)
|
Ensembl | 815 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cryaa:crygm2d1-GFP) |
|
| 1 | Shao et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-212N6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109890 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:112327 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173493 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192065 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020681 (1) | 654 nt | ||
| Genomic | GenBank:CR854911 (1) | 233522 nt | ||
| Polypeptide | UniProtKB:B0S6M3 (1) | 175 aa |
No data available
- Fu, J.L., Zheng, S.Y., Wang, Y., Hu, X.B., Xiao, Y., Wang, J.M., Zhang, L., Wang, L., Nie, Q., Hou, M., Bai, Y.Y., Gan, Y.W., Liang, X.M., Xie, L.L., Li, D.W. (2023) HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221522120e2221522120
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Shao, M., Lu, T., Zhang, C., Zhang, Y.Z., Kong, S.H., Shi, D.L. (2020) Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation. Proceedings of the National Academy of Sciences of the United States of America. 117:7245-7254
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Zhang, L., Yang, Y., Li, B., Scott, I.C., Lou, X. (2018) The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development (Cambridge, England). 145(8)
- Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuzé, A., Casane, D., Rétaux, S. (2015) Lens defects in Astyanax mexicanus cavefish: evolution of crystallins and a role for alphaA-crystallin. Developmental Neurobiology. 75(5):505-21
- Choudhuri, A., Maitra, U., and Evans, T. (2013) Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110(24):9818-9823
- Konzer, A., Ruhs, A., Braun, H., Jungblut, B., Braun, T., and Krueger, M. (2013) Stable Isotope Labeling in Zebrafish Allows in Vivo Monitoring of Cardiac Morphogenesis. Molecular & cellular proteomics : MCP. 12(6):1502-12
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