Gene
fabp4b
- ID
- ZDB-GENE-050522-391
- Name
- fatty acid binding protein 4b
- Symbol
- fabp4b Nomenclature History
- Previous Names
-
- fabp11b
- fabp11l
- zgc:110029
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity. Acts upstream of or within response to prostaglandin and response to vitamin B3. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; heart; ovary; and presumptive retinal pigmented epithelium. Orthologous to several human genes including FABP4 (fatty acid binding protein 4) and FABP9 (fatty acid binding protein 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110029 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42690 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein | Lipocalin/cytosolic fatty-acid binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q503X5 | InterPro | 134 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fabp11b-201
(1)
|
Ensembl | 636 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110029 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192586 | ZFIN Curated Data | |
| interacts with | Promoter | fabp11b_promoter | Laprairie et al., 2017 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020558 (1) | 643 nt | ||
| Genomic | GenBank:BX248082 (1) | 152455 nt | ||
| Polypeptide | UniProtKB:Q503X5 (1) | 134 aa |
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083
- Laprairie, R.B., Denovan-Wright, E.M., Wright, J.M. (2017) Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 213:81-90
- Zhang, J., Qi, J., Wu, S., Peng, L., Shi, Y., Yang, J., Yin, Z., Gao, Y., Wang, C., Gong, J., Zhang, H., Zhang, J., Liu, D. (2017) Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in Physiology. 8:214
- Arnold, C.R., Lamont, R.E., Walker, J.T., Spice, P.J., Chan, C.K., Ho, C.Y., Childs, S.J. (2015) Comparative analysis of genes regulated by Dzip1/iguana and Hedgehog in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):211-23
- Lee, Y.J., Choi, H.S., Seo, M.J., Jeon, H.J., Kim, K.J., Lee, B.Y. (2015) Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish. Food & function. 6(8):2824-33
- Seo, M.J., Choi, H.S., Jeon, H.J., Woo, M.S., Lee, B.Y. (2014) Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 67:57-64
- Thirumaran, A., Wright, J.M. (2014) Fatty acid-binding protein (fabp) genes of spotted green pufferfish (Tetraodon nigroviridis): comparative genomics and spatial transcriptional regulation. Genome. 57(5):289-301
- Wiweger, M.I., de Andrea, C.E., Scheepstra, K.W., Zhao, Z., Hogendoorn, P.C. (2014) Possible effects of EXT2 on mesenchymal differentiation--lessons from the zebrafish. Orphanet journal of rare diseases. 9:35
- Parmar, M.B., and Wright, J.M. (2013) Comparative evolutionary genomics of medaka and three-spined stickleback fabp2a and fabp2b genes with fabp2 of zebrafish. Genome. 56(1):27-37
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