Gene
dnai4
- ID
- ZDB-GENE-050522-322
- Name
- dynein axonemal intermediate chain 4
- Symbol
- dnai4 Nomenclature History
- Previous Names
-
- wdr78
- zgc:111979
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Acts upstream of or within cilium movement. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. Is expressed in several structures, including Kupffer's vesicle; hindbrain neural plate; nervous system; otic vesicle; and pronephric duct. Used to study ciliopathy. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111979 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zhang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dnai4 | N/A | Zhang et al., 2018 |
| MO2-dnai4 | N/A | Zhang et al., 2018 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO2-dnai4 | standard conditions | Zhang et al., 2018 |
| ciliopathy | WT + MO1-dnai4 | standard conditions | Zhang et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:F1QHZ6 | InterPro | 778 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-218B7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111979 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020759 (1) | 2933 nt | ||
| Genomic | GenBank:BX088595 (1) | 143341 nt | ||
| Polypeptide | UniProtKB:F1QHZ6 (1) | 778 aa |
- Zhang, Y., Chen, Y., Zheng, J., Wang, J., Duan, S., Zhang, W., Yan, X., Zhu, X. (2018) Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Journal of molecular cell biology. 11(5):383-394
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Vij, S., Rink, J.C., Ho, H.K., Babu, D., Eitel, M., Narasimhan, V., Tiku, V., Westbrook, J., Schierwater, B., and Roy, S. (2012) Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program. PLoS Genetics. 8(11):e1003019
- Yu, X., Ng, C.P., Habacher, H., and Roy, S. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics. 40(12):1445-1453
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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