Gene
dnai4
- ID
- ZDB-GENE-050522-322
- Name
- dynein axonemal intermediate chain 4
- Symbol
- dnai4 Nomenclature History
- Previous Names
-
- wdr78
- zgc:111979
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to contribute to plus-end-directed microtubule motor activity. Acts upstream of or within cilium movement. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. Is expressed in several structures, including Kupffer's vesicle; hindbrain neural plate; nervous system; otic vesicle; and pronephric duct. Used to study ciliopathy. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111979 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zhang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO2-dnai4 | standard conditions | Zhang et al., 2018 |
| ciliopathy | WT + MO1-dnai4 | standard conditions | Zhang et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1QHZ6
|
778 |
Interactions and Pathways
No data available
Plasmids
No data available