Gene
alkbh1
- ID
- ZDB-GENE-050522-196
- Name
- alkB homolog 1, histone H2A dioxygenase
- Symbol
- alkbh1 Nomenclature History
- Previous Names
-
- si:ch211-133l14.1
- zgc:112365
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable broad specificity oxidative DNA demethylase activity; ferrous iron binding activity; and oxidative RNA demethylase activity. Predicted to be involved in oxidative RNA demethylation. Predicted to act upstream of or within DNA repair. Predicted to be active in cytoplasm and nucleus. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027816Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Family | IPR004574 | Alkylated DNA repair protein AlkB |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkylated DNA repair protein AlkB | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Oxoglutarate/iron-dependent dioxygenase domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B5M4 | InterPro | 329 | ||||
| UniProtKB:Q502A8 | InterPro | 363 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
alkbh1-202
(1)
|
Ensembl | 1,032 nt | ||
| mRNA |
alkbh1-201
(1)
|
Ensembl | 1,214 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020691 (1) | 1229 nt | ||
| Genomic | GenBank:CU855697 (2) | 130734 nt | ||
| Polypeptide | UniProtKB:Q502A8 (1) | 363 aa |
- Fernandes, S.B., Grova, N., Roth, S., Duca, R.C., Godderis, L., Guebels, P., Mériaux, S.B., Lumley, A.I., Bouillaud-Kremarik, P., Ernens, I., Devaux, Y., Schroeder, H., Turner, J.D. (2021) N6-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity. Frontiers in genetics. 12:657171
- Sun, Q., Liu, X., Gong, B., Wu, D., Meng, A., Jia, S. (2017) Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. International journal of biological sciences. 13:1051-1066
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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