Gene

tpmt.1

ID
ZDB-GENE-050522-141
Name
thiopurine S-methyltransferase, tandem duplicate 1
Symbol
tpmt.1 Nomenclature History
Previous Names
  • si:ch73-345a19.2
  • zgc:109981
  • zgc:92752
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have thiopurine S-methyltransferase activity. Predicted to be involved in methylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpmt.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thiopurine S-methyltransferase deficiency Alliance {Thiopurines, poor metabolism of, 1} 610460
Associated With tpmt.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008854 TPMT family
Family IPR025835 Thiopurine S-methyltransferase
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length S-adenosyl-L-methionine-dependent methyltransferase Thiopurine S-methyltransferase TPMT family
UniProtKB:Q6DGV9 84
UniProtKB:Q504A5 232
UniProtKB:B2GPF4 232
UniProtKB:B8JKP3 231
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations