Gene

tpmt.1

ID
ZDB-GENE-050522-141
Name
thiopurine S-methyltransferase, tandem duplicate 1
Symbol
tpmt.1 Nomenclature History
Previous Names
  • si:ch73-345a19.2
  • zgc:109981
  • zgc:92752
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have thiopurine S-methyltransferase activity. Predicted to be involved in methylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpmt.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thiopurine S-methyltransferase deficiency Alliance {Thiopurines, poor metabolism of, 1} 610460
Associated With tpmt.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008854 TPMT family
Family IPR025835 Thiopurine S-methyltransferase
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length S-adenosyl-L-methionine-dependent methyltransferase Thiopurine S-methyltransferase TPMT family
UniProtKB:Q504A5 232
UniProtKB:Q6DGV9 84
UniProtKB:B8JKP3 231
UniProtKB:B2GPF4 232
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations