Gene
ints11
- ID
- ZDB-GENE-050522-13
- Name
- integrator complex subunit 11
- Symbol
- ints11 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable RNA endonuclease activity. Acts upstream of or within regulation of RNA splicing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Tao et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities | Alliance | Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities | 620428 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001279 | Metallo-beta-lactamase |
| Domain | IPR011108 | Zn-dependent metallo-hydrolase, RNA specificity domain |
| Domain | IPR022712 | Beta-Casp domain |
| Domain | IPR041897 | Integrator complex subunit 11, MBL-fold |
| Domain | IPR048662 | Integrator complex subunit 11, C-terminal domain |
| Family | IPR050698 | RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein |
| Homologous_superfamily | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Details Per Protein
| Protein | Length | Beta-Casp domain | Integrator complex subunit 11, C-terminal domain | Integrator complex subunit 11, MBL-fold | Metallo-beta-lactamase | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like | RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein | Zn-dependent metallo-hydrolase, RNA specificity domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QEY5
|
598 | |||||||
|
UniProtKB:Q503E1
|
598 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ints11-201
(1)
|
Ensembl | 7,259 nt | ||
| mRNA |
ints11-202
(1)
|
Ensembl | 1,740 nt | ||
| mRNA |
ints11-203
(1)
|
Ensembl | 937 nt |
Interactions and Pathways
No data available
Plasmids
No data available