Gene
abcg8
- ID
- ZDB-GENE-050517-41
- Name
- ATP-binding cassette, sub-family G (WHITE), member 8
- Symbol
- abcg8 Nomenclature History
- Previous Names
-
- sterolin 2
- zgc:172358
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to contribute to cholesterol transfer activity. Predicted to be involved in cholesterol efflux; cholesterol homeostasis; and transmembrane transport. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pinto et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| gallbladder disease | Alliance | {Gallbladder disease 4} | 611465 |
| sitosterolemia 1 | Alliance | Sitosterolemia 1 | 210250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
| Domain | IPR043926 | ABC transporter family G domain |
| Family | IPR050352 | ATP-binding cassette subfamily G transporters |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter family G domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ATP-binding cassette subfamily G transporters | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IJR4
|
675 | |||||||
|
UniProtKB:A0A0R4IGG8
|
676 | |||||||
|
UniProtKB:A0A8M1NFQ3
|
684 |
Interactions and Pathways
No data available
Plasmids
No data available