Gene

abcd1

ID
ZDB-GENE-050517-27
Name
ATP-binding cassette, sub-family D (ALD), member 1
Symbol
abcd1 Nomenclature History
Previous Names
  • zgc:172102 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including oligodendrocyte development; positive regulation of myelination; and swimming behavior. Predicted to localize to peroxisomal membrane. Is expressed in central nervous system; floor plate; gut; interrenal gland; and pronephros. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Strachan et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcd1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adrenoleukodystrophy Alliance Adrenoleukodystrophy 300100
adrenoleukodystrophy Alliance Adrenomyeloneuropathy, adult 300100
Associated With abcd1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Family IPR031237 ATP-binding cassette sub-family D member 1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter, conserved site ABC transporter-like ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily ATP-binding cassette sub-family D member 1 P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1RBC8 766
UniProtKB:A9JRC4 640
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations