Gene
abca2
- ID
- ZDB-GENE-050517-1
- Name
- ATP-binding cassette, sub-family A (ABC1), member 2
- Symbol
- abca2 Nomenclature History
- Previous Names
-
- si:dkey-266h7.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Orthologous to human ABCA2 (ATP binding cassette subfamily A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024916Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9569 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18415 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33596 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33597 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40423 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40424 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40425 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45201 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 9 of 9
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with poor growth and with or without seizures or ataxia | 618808 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
| Domain | IPR056264 | ABCA1-4-like, C-terminal R2 regulatory domain |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABCA1-4-like, C-terminal R2 regulatory domain | ABC transporter A | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCG2 | InterPro | 2504 | |||||||
| UniProtKB:A0A8M2BCJ8 | InterPro | 2503 | |||||||
| UniProtKB:A0A8M2BCH1 | InterPro | 2503 | |||||||
| UniProtKB:A0AB32TQ63 | InterPro | 2502 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28C10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-266H7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:165546 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102643 (1) | 1093 nt | ||
| Genomic | GenBank:BX842685 (2) | 133388 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCG2 (1) | 2504 aa |
- Lu, X., Tian, J., Wen, H., Jiang, M., Liu, W., Wu, F., Yu, L., Zhong, S. (2019) Microcystin-LR-regulated transcriptome dynamics in ZFL cells. Aquatic toxicology (Amsterdam, Netherlands). 212:222-232
- Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018) Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M. (2006) Evolution of the vertebrate ABC gene family: Analysis of gene birth and death. Genomics. 88(1):1-11
- Dean, M., and Annilo, T. (2005) Evolution of the ATP-Binding Cassette (ABC) Transporter Superfamily in Vertebrates. Annual review of genomics and human genetics. 6:123-142
1 - 10 of 11
Show