Gene
gcgra
- ID
- ZDB-GENE-050516-1
- Name
- glucagon receptor a
- Symbol
- gcgra Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Exhibits glucagon receptor activity and peptide hormone binding activity. Involved in regulation of glucose metabolic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in brain; heart; liver; and muscle. Orthologous to human GCGR (glucagon receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Li et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mahvash Disease | Alliance | Mahvash disease | 619290 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR001749 | GPCR, family 2, gastric inhibitory polypeptide receptor |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2, gastric inhibitory polypeptide receptor | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YWT8
|
512 | |||||||
|
UniProtKB:E7FB43
|
520 |
Interactions and Pathways
No data available
Plasmids
No data available