Gene
sema3c
- ID
- ZDB-GENE-050513-5
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
- Symbol
- sema3c Nomenclature History
- Previous Names
-
- si:dkey-105o6.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables neuropilin binding activity. Acts upstream of or within enteric nervous system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in caudal tuberculum and otic vesicle. Orthologous to human SEMA3C (semaphorin 3C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015373Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1359 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12671 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15161 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30849 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sema3c | van der Klaauw et al., 2019 | |
| CRISPR2-sema3c | van der Klaauw et al., 2019 | |
| CRISPR3-sema3c | van der Klaauw et al., 2019 | |
| MO1-sema3c | N/A | Jiang et al., 2015 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z658 | InterPro | 757 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3c-201
(1)
|
Ensembl | 2,141 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27K7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-105O6 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017355318 (1) | 5733 nt | ||
| Genomic | GenBank:BX537168 (2) | 200744 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z658 (1) | 757 aa |
- Britto, D.D., He, J., Misa, J.P., Chen, W., Kakadia, P.M., Grimm, L., Herbert, C.D., Crosier, K.E., Crosier, P.S., Bohlander, S.K., Hogan, B.M., Hall, C.J., Torres-Vázquez, J., Astin, J.W. (2022) Plexind1 negatively regulates zebrafish lymphatic development. Development (Cambridge, England). 149(21)
- Tsata, V., Kroehne, V., Wehner, D., Rost, F., Lange, C., Hoppe, C., Kurth, T., Reinhardt, S., Petzold, A., Dahl, A., Loeffler, M., Reimer, M.M., Brand, M. (2020) Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord. Development (Cambridge, England). 147(24):
- He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Hörnberg, H., Cioni, J.M., Harris, W.A., Holt, C.E. (2016) Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:12697-12706
- Taku, A.A., Marcaccio, C.L., Ye, W., Krause, G.J., Raper, J.A. (2016) Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target. Development (Cambridge, England). 143:123-32
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Fink, I.R., Benard, E.L., Hermsen, T., Meijer, A.H., Forlenza, M., Wiegertjes, G.F. (2015) Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Molecular immunology. 63(2):381-93
- Jiang, Q., Arnold, S., Heanue, T., Kilambi, K.P., Doan, B., Kapoor, A., Ling, A.Y., Sosa, M.X., Guy, M., Jiang, Q., Burzynski, G., West, K., Bessling, S., Griseri, P., Amiel, J., Fernandez, R.M., Verheij, J.B., Hofstra, R.M., Borrego, S., Lyonnet, S., Ceccherini, I., Gray, J.J., Pachnis, V., McCallion, A.S., Chakravarti, A. (2015) Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability. American journal of human genetics. 96:581-596
1 - 10 of 15
Show