Gene

eps8l1b

ID

ZDB-GENE-050506-143

Name

EPS8 signaling adaptor L1b

Symbol

eps8l1b Nomenclature History

Previous Names

im:7147678 (1)
si:ch73-70c5.1

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to localize to ruffle membrane. Orthologous to human EPS8L1 (EPS8 like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147678 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eps8l1b Human Ortholog

No data available

Associated With eps8l1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR013625	Tensin/EPS8 phosphotyrosine-binding domain
Domain	IPR041418	SAM domain
Family	IPR039801	Epidermal growth factor receptor kinase substrate 8-like
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Epidermal growth factor receptor kinase substrate 8-like	PH-like domain superfamily	SAM domain	SH3 domain	SH3-like domain superfamily	Sterile alpha motif/pointed domain superfamily	Tensin/EPS8 phosphotyrosine-binding domain
UniProtKB:E7F1L9 InterPro	505
UniProtKB:A0A8M2BI52 InterPro	649

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eps8l1b-202 (1) Ensembl	Ensembl	734 nt	Select Tool ZFIN BLAST
mRNA	eps8l1b-203 (1) Ensembl	Ensembl	2,635 nt	Select Tool ZFIN BLAST
ncRNA	si:ch73-70c5.1-003 (1) Ensembl	Ensembl	554 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations