Gene
fermt2
- ID
- ZDB-GENE-050506-132
- Name
- FERM domain containing kindlin 2
- Symbol
- fermt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within cell migration; circulatory system development; and cytoskeleton organization. Located in intercalated disc. Is expressed in several structures, including forerunner cell group; head mesenchyme; heart; myotome; and notochord. Orthologous to human FERMT2 (FERM domain containing kindlin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145859 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb492 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb531 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la020204Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020205Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027882Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36538 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fermt2 | Zebrafish Nomenclature Committee | |
| CRISPR2-fermt2 | Zebrafish Nomenclature Committee | |
| MO1-fermt2 | N/A | (4) |
| MO2-fermt2 | N/A | (3) |
| MO3-fermt2 | N/A | Yasuda-Yamahara et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR037837 | Kindlin/fermitin, PH domain |
| Domain | IPR040790 | Kindlin-2, N-terminal |
| Family | IPR037843 | Kindlin/fermitin |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM central domain | FERM superfamily, second domain | Kindlin-2, N-terminal | Kindlin/fermitin | Kindlin/fermitin, PH domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8RR15 | InterPro | 688 | ||||||||
| UniProtKB:A0A2R8QN11 | InterPro | 695 | ||||||||
| UniProtKB:A0A8M2B5V7 | InterPro | 677 | ||||||||
| UniProtKB:F1Q8X5 | InterPro | 684 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fermt2-201
(1)
|
Ensembl | 2,488 nt | ||
| mRNA |
fermt2-203
(1)
|
Ensembl | 2,430 nt | ||
| mRNA |
fermt2-204
(1)
|
Ensembl | 2,409 nt | ||
| ncRNA |
fermt2-002
(1)
|
Ensembl | 840 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127L5 | ||
| Encodes | EST | IMAGE:7145859 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256215 (1) | 2488 nt | ||
| Genomic | GenBank:AL928709 (2) | 166456 nt | ||
| Polypeptide | UniProtKB:A0A2R8QN11 (1) | 695 aa |
- Chen, L., Zhong, S., Wang, Y., Wang, X., Liu, Z., Hu, G. (2023) Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. International Journal of Molecular Sciences. 24(19):
- Li, W., Wen, L., Rathod, B., Gingras, A.C., Ley, K., Lee, H.S. (2022) Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development. Life science alliance. 6(3):
- Yasuda-Yamahara, M., Rogg, M., Frimmel, J., Trachte, P., Helmstaedter, M., Schroder, P., Schiffer, M., Schell, C., Huber, T.B. (2018) FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix biology : journal of the International Society for Matrix Biology. 68-69:263-279
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Fitzpatrick, P., Shattil, S.J., Ablooglu, A.J. (2014) C-terminal COOH of Integrin beta1 Is Necessary for beta1 Association with the Kindlin-2 Adapter Protein. The Journal of biological chemistry. 289:11183-93
- Todd, P.K., Ackall, F.Y., Hur, J., Sharma, K., Paulson, H.L., and Dowling, J.J. (2014) Transcriptional changes and developmental abnormalities in a Zebrafish model of Myotonic Dystrophy Type 1. Disease models & mechanisms. 7(1):143-55
- Catterson, J.H., Heck, M.M., and Hartley, P.S. (2013) Fermitins, the Orthologs of Mammalian Kindlins, Regulate the Development of a Functional Cardiac Syncytium in Drosophila melanogaster. PLoS One. 8(5):e62958
- Postel, R., Margadant, C., Fischer, B., Kreft, M., Janssen, H., Secades, P., Zambruno, G., and Sonnenberg, A. (2013) Kindlin-1 mutant zebrafish as an in vivo model sytem to study adhesion mechanisms in the epidermis. The Journal of investigative dermatology. 133(9):2180-90
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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