Gene

fgd4a

ID

ZDB-GENE-050420-347

Name

FYVE, RhoGEF and PH domain containing 4a

Symbol

fgd4a Nomenclature History

Previous Names

fgd4
si:ch211-194i18.1
si:dkey-57m7.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Is expressed in basal plate midbrain region; diencephalon; and tegmentum. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4).

Genome Resources

Note

This gene has an almost identical sequence to si:dkey-57m7.1. The EST CK683166 matches both.

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145382 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgd4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4H	Alliance	Charcot-Marie-Tooth disease, type 4H	609311

Associated With fgd4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000306	FYVE zinc finger
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR035941	FGD1-4, C-terminal PH domain
Domain	IPR037742	FGD4, N-terminal PH domain
Family	IPR051092	FYVE, RhoGEF and PH domain-containing
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily