Gene
srgap1a
- ID
- ZDB-GENE-050420-284
- Name
- SLIT-ROBO Rho GTPase activating protein 1a
- Symbol
- srgap1a Nomenclature History
- Previous Names
-
- srgap1
- si:ch211-238a12.4
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have Rac GTPase binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| follicular thyroid carcinoma | Alliance | {Thyroid cancer, nonmedullary, 2} | 188470 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035648 | srGAP1/2/3, SH3 domain |
| Domain | IPR037451 | SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain |
| Family | IPR051627 | SLIT-ROBO Rho GTPase-activating |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | SLIT-ROBO Rho GTPase-activating | SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain | srGAP1/2/3, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YW41
|
987 | ||||||||||
|
UniProtKB:F1Q4Y5
|
1073 | ||||||||||
|
UniProtKB:A0A8M9Q6U7
|
179 | ||||||||||
|
UniProtKB:A0A8M6Z228
|
1096 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srgap1a-201
(1)
|
Ensembl | 3,222 nt | ||
| mRNA |
srgap1a-202
(1)
|
Ensembl | 3,212 nt |
Interactions and Pathways
No data available
Plasmids
No data available