Gene
srgap1a
- ID
- ZDB-GENE-050420-284
- Name
- SLIT-ROBO Rho GTPase activating protein 1a
- Symbol
- srgap1a Nomenclature History
- Previous Names
-
- srgap1
- si:ch211-238a12.4
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23247 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25055 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32190 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36592 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43064 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43065 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| follicular thyroid carcinoma | Alliance | {Thyroid cancer, nonmedullary, 2} | 188470 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | SLIT-ROBO Rho GTPase-activating | SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain | srGAP1/2/3, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YW41 | InterPro | 987 | ||||||||||
| UniProtKB:F1Q4Y5 | InterPro | 1073 | ||||||||||
| UniProtKB:A0A8M9Q6U7 | InterPro | 179 | ||||||||||
| UniProtKB:A0A8M6Z228 | InterPro | 1096 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srgap1a-201
(1)
|
Ensembl | 3,222 nt | ||
| mRNA |
srgap1a-202
(1)
|
Ensembl | 3,212 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-227D19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-238A12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-18H23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017352030 (1) | |||
| Genomic | GenBank:BX927072 (1) | 157662 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z228 (1) | 1096 aa |
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haug, M.F., Gesemann, M., Lazovic, V., Neuhauss, S.C. (2015) Eumetazoan Cryptochrome Phylogeny and Evolution. Genome biology and evolution. 7(2):601-19
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