Gene
dclk2a
- ID
- ZDB-GENE-050420-170
- Name
- doublecortin-like kinase 2a
- Symbol
- dclk2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables protein serine/threonine kinase activity. Acts upstream of or within hyperosmotic response and protein autophosphorylation. Located in microtubule cytoskeleton; nucleus; and synaptic vesicle. Is expressed in several structures, including hindbrain neural plate; immature eye; nervous system; optic primordium; and trigeminal placode. Orthologous to human DCLK2 (doublecortin like kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb572 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shimomura et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003533 | Doublecortin domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Doublecortin domain | Doublecortin domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AQY6 | InterPro | 801 | ||||||
| UniProtKB:A2A123 | InterPro | 725 | ||||||
| UniProtKB:A2A124 | InterPro | 722 | ||||||
| UniProtKB:A2A121 | InterPro | 810 | ||||||
| UniProtKB:A2A122 | InterPro | 791 |
1 - 5 of 5
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dclk2a-201
(1)
|
Ensembl | 2,294 nt | ||
| mRNA |
dclk2a-202
(1)
|
Ensembl | 4,524 nt | ||
| mRNA |
dclk2a-203
(1)
|
Ensembl | 2,703 nt | ||
| mRNA |
dclk2a-204
(1)
|
Ensembl | 2,642 nt | ||
| mRNA |
dclk2a-205
(1)
|
Ensembl | 2,333 nt |
1 - 5 of 14 Show all
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(Xla.Eef1a1:dclk2DeltaK-GFP) |
|
| 1 | (7) | |
| Tg(Xla.Eef1a1:dclk2a-GFP) |
|
| 1 | (21) |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-180N16 | ZFIN Curated Data | |
| Encodes | EST | cb572 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:174949 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195357 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001081693 (1) | 2729 nt | ||
| Genomic | GenBank:BX005385 (2) | 159174 nt | ||
| Polypeptide | UniProtKB:A2A121 (1) | 810 aa |
- Bernardello, M., Gualda, E.J., Loza-Alvarez, P. (2022) Modular multimodal platform for classical and high throughput light sheet microscopy. Scientific Reports. 12:1969
- DeOliveira-Mello, L., Vicente, I., Gonzalez-Nunez, V., Santos-Ledo, A., Velasco, A., Arévalo, R., Lara, J.M., Mack, A.F. (2022) Doublecortin in the Fish Visual System, a Specific Protein of Maturing Neurons. Biology. 11(2):
- Fasano, G., Muto, V., Radio, F.C., Venditti, M., Mosaddeghzadeh, N., Coppola, S., Paradisi, G., Zara, E., Bazgir, F., Ziegler, A., Chillemi, G., Bertuccini, L., Tinari, A., Vetro, A., Pantaleoni, F., Pizzi, S., Conti, L.A., Petrini, S., Bruselles, A., Prandi, I.G., Mancini, C., Chandramouli, B., Barth, M., Bris, C., Milani, D., Selicorni, A., Macchiaiolo, M., Gonfiantini, M.V., Bartuli, A., Mariani, R., Curry, C.J., Guerrini, R., Slavotinek, A., Iascone, M., Dallapiccola, B., Ahmadian, M.R., Lauri, A., Tartaglia, M. (2022) Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish. Nature communications. 13:6841
- Marsal, M., Bernardello, M., Gualda, E.J., Loza-Alvarez, P. (2022) Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly. Scientific Reports. 12:4072
- Willekers, S., Tessadori, F., van der Vaart, B., Henning, H.H., Stucchi, R., Altelaar, M., Roelen, B.A.J., Akhmanova, A., Bakkers, J. (2022) The centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryo. Development (Cambridge, England). 149(16)
- Bernardello, M., Marsal, M., Gualda, E.J., Loza-Alvarez, P. (2021) Light-sheet fluorescence microscopy for the in vivo study of microtubule dynamics in the zebrafish embryo. Biomedical Optics Express. 12:6237-6254
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Willoughby, P.M., Allen, M., Yu, J., Korytnikov, R., Chen, T., Liu, Y., So, I., Macpherson, N., Mitchell, J.A., Fernandez-Gonzalez, R., Bruce, A.E.E. (2021) The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium. eLIFE. 10:
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Rutherford, N.E., Wong, A.H., Bruce, A.E.E. (2019) Spatio-temporal characterization of dynamic epithelial filopodia during zebrafish epiboly. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):997-1008
1 - 10 of 33
Show