Gene

otogl

ID
ZDB-GENE-050419-93
Name
otogelin-like
Symbol
otogl Nomenclature History
Previous Names
  • si:dkeyp-27b10.2 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have alpha-L-arabinofuranosidase activity. Involved in otolith morphogenesis; semicircular canal morphogenesis; and sensory perception of sound. Predicted to localize to extracellular matrix and extracellular space. Is expressed in inner ear; macula utricle; and otolith. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 84B. Orthologous to human OTOGL (otogelin like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Yariz et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With otogl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 84B Alliance Deafness, autosomal recessive 84B 614944
Associated With otogl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001846 von Willebrand factor, type D domain
Domain IPR002919 Trypsin Inhibitor-like, cysteine rich domain
Domain IPR006207 Cystine knot, C-terminal
Domain IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain
Domain IPR014853 Uncharacterised domain, cysteine-rich
Family IPR030110 Otogelin-like protein
Homologous_superfamily IPR036084 Serine protease inhibitor-like superfamily
Homologous_superfamily IPR036195 Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-L-arabinofuranosidase B, arabinose-binding domain Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily Cystine knot, C-terminal Otogelin-like protein Serine protease inhibitor-like superfamily Trypsin Inhibitor-like, cysteine rich domain Uncharacterised domain, cysteine-rich von Willebrand factor, type D domain
UniProtKB:F1Q539 2489
UniProtKB:A0A286YAF1 2146
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations