Gene

skor1b

ID

ZDB-GENE-050419-82

Name

SKI family transcriptional corepressor 1b

Symbol

skor1b Nomenclature History

Previous Names

si:dkey-246a16.3 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in Purkinje cell. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Takeuchi et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With skor1b Human Ortholog

No data available

Associated With skor1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003380	SKI/SNO/DAC domain
Domain	IPR014890	c-SKI SMAD4-binding domain
Family	IPR023216	Transcription regulator SKI/SnoN
Homologous_superfamily	IPR009061	Putative DNA-binding domain superfamily
Homologous_superfamily	IPR010919	SAND-like domain superfamily
Homologous_superfamily	IPR037000	Ski-like, DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	c-SKI SMAD4-binding domain	Putative DNA-binding domain superfamily	SAND-like domain superfamily	Ski-like, DNA-binding domain superfamily	SKI/SNO/DAC domain	Transcription regulator SKI/SnoN
UniProtKB:A0A0R4I9E1 InterPro	750
UniProtKB:Q1LXZ9 InterPro	751
UniProtKB:A0A8M2B643 InterPro	748

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	skor1b-201 (1) Ensembl	Ensembl	4,022 nt	Select Tool ZFIN BLAST
mRNA	skor1b-202 (1) Ensembl	Ensembl	2,256 nt	Select Tool ZFIN BLAST
mRNA	skor1b-203 (1) Ensembl	Ensembl	3,629 nt	Select Tool ZFIN BLAST
mRNA	skor1b-204 (1) Ensembl	Ensembl	5,406 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations