Gene
zbtb18
- ID
- ZDB-GENE-050419-73
- Name
- zinc finger and BTB domain containing 18
- Symbol
- zbtb18 Nomenclature History
- Previous Names
-
- si:ch211-221n23.1
- znf238
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; optic cup; and somite. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 22 | Alliance | Intellectual developmental disorder, autosomal dominant 22 | 612337 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | SKP1/BTB/POZ domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
| UniProtKB:Q1L8W0 | InterPro | 537 | ||||
| UniProtKB:A0AB13ABQ4 | InterPro | 546 | ||||
| UniProtKB:A0AB32U3Q5 | InterPro | 558 | ||||
| UniProtKB:A0AB32U4L5 | InterPro | 552 | ||||
| UniProtKB:A0AB32U4W4 | InterPro | 537 | ||||
| UniProtKB:A0AB32U5N2 | InterPro | 547 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zbtb18-201
(1)
|
Ensembl | 638 nt | ||
| mRNA |
zbtb18-202
(1)
|
Ensembl | 6,971 nt | ||
| mRNA |
zbtb18-203
(1)
|
Ensembl | 2,485 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-221N23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082952 (1) | 5024 nt | ||
| Genomic | GenBank:CR589882 (1) | 205759 nt | ||
| Polypeptide | UniProtKB:A0AB32U3Q5 (1) | 558 aa |
- Al Qaryoute, A., Fallatah, W., Dhinoja, S., Raman, R., Jagadeeswaran, P. (2023) Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. Scientific Reports. 13:1606616066
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):
- Diotel, N., Beil, T., Strähle, U., Rastegar, S. (2015) Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Gene expression patterns : GEP. 19(1-2):1-13
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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