Gene
zfpm1
- ID
- ZDB-GENE-050419-238
- Name
- zinc finger protein, FOG family member 1
- Symbol
- zfpm1 Nomenclature History
- Previous Names
-
- fog1 (1)
- si:dkey-20g6.1
- si:dkey-38l12.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; metal ion binding activity; and transcription corepressor activity. Acts upstream of or within heart looping and hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including intermediate cell mass of mesoderm; lateral plate mesoderm; myeloid cell; otic vesicle; and pericardial region. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10486 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36618 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36619 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| nju204 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| nju207 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| nju208 | Allele with one deletion | Exon 6 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zfpm1 | (2) | |
| CRISPR2-zfpm1 | (2) | |
| CRISPR3-zfpm1 | (2) | |
| CRISPR4-zfpm1 | (2) | |
| CRISPR5-zfpm1 | (2) | |
| CRISPR6-zfpm1 | (2) | |
| CRISPR7-zfpm1 | (2) | |
| CRISPR8-zfpm1 | (2) | |
| CRISPR9-zfpm1 | (2) | |
| CRISPR10-zfpm1 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FOG family | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger CCHC FOG-type | Zinc finger protein ZFPM1/2, PR domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:P60622 | InterPro | 224 | |||||
| UniProtKB:Q2QKK0 | InterPro | 1191 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(zfpm1:EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-74E13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-239N6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-20G6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38L12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-225B14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039460 (1) | 4217 nt | ||
| Genomic | GenBank:BX470162 (1) | 215723 nt | ||
| Polypeptide | UniProtKB:Q2QKK0 (1) | 1191 aa |
- Lin, Q., Zhou, R., Meng, P., Wu, L., Yang, L., Liu, W., Wu, J., Cheng, Y., Shi, L., Zhang, Y. (2021) Establishment of a Bernard-Soulier syndrome model in zebrafish. Haematologica. 107(7):1655-1668
- Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150
- Bräutigam, L., Zhang, J., Dreij, K., Spahiu, L., Holmgren, A., Abe, H., Tew, K.D., Townsend, D.M., Kelner, M.J., Morgenstern, R., Johansson, K. (2018) MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biology. 17:171-179
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216
- Place, E.S., Smith, J.C. (2017) Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes. PLoS One. 12:e0171143
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441
- Rawnsley, D.R., Xiao, J., Lee, J.S., Liu, X., Mericko-Ishizuka, P., Kumar, V., He, J., Basu, A., Lu, M., Lynn, F.C., Pack, M., Gasa, R., Kahn, M.L. (2013) The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. The Journal of biological chemistry. 288:24429-40
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