Gene
tango6
- ID
- ZDB-GENE-050419-237
- Name
- transport and golgi organization 6 homolog (Drosophila)
- Symbol
- tango6 Nomenclature History
- Previous Names
-
- si:ch211-218c6.2 (1)
- tmco7
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to be involved in protein secretion. Orthologous to human TANGO6 (transport and golgi organization 6 homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36615 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019414 | RNA polymerase II assembly factor Rtp1, C-terminal domain 2 |
| Domain | IPR019451 | RNA polymerase II assembly factor Rtp1, C-terminal |
| Family | IPR039600 | TANGO6/Rtp1 |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | RNA polymerase II assembly factor Rtp1, C-terminal | RNA polymerase II assembly factor Rtp1, C-terminal domain 2 | TANGO6/Rtp1 |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q077 | InterPro | 1065 | |||||
| UniProtKB:A0A8M9PAD5 | InterPro | 1064 | |||||
| UniProtKB:A0A8N7UVK3 | InterPro | 1064 | |||||
| UniProtKB:A0A2R8Q2U0 | InterPro | 1065 | |||||
| UniProtKB:A0AB32T6D4 | InterPro | 925 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tango6-201
(1)
|
Ensembl | 5,332 nt | ||
| mRNA |
tango6-202
(1)
|
Ensembl | 3,219 nt | ||
| mRNA |
tango6-203
(1)
|
Ensembl | 7,055 nt | ||
| mRNA |
tango6-204
(1)
|
Ensembl | 7,166 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218C6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214890 (1) | 3222 nt | ||
| Genomic | GenBank:BX323598 (1) | 197329 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q077 (1) | 1065 aa |
- Liu, S., Feng, Z., Su, M., Liu, C., Xi, Y., Chen, H., Luo, L., Tian, X., Zhao, F., Li, L. (2024) Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue. Development (Cambridge, England). 152(1):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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