Gene

cngb1a

ID

ZDB-GENE-050419-164

Name

cyclic nucleotide gated channel subunit beta 1a

Symbol

cngb1a Nomenclature History

Previous Names

si:ch211-160j6.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport and retina homeostasis. Predicted to act upstream of or within visual perception. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Predicted to be active in photoreceptor outer segment and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cngb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 45	Alliance	Retinitis pigmentosa 45	613767

Associated With cngb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018488	Cyclic nucleotide-binding, conserved site
Domain	IPR000595	Cyclic nucleotide-binding domain
Family	IPR050866	Cyclic nucleotide-gated cation channel
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily

Domain Details Per Protein

Protein	Length	Cyclic nucleotide-binding, conserved site	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	Cyclic nucleotide-gated cation channel	RmlC-like jelly roll fold
UniProtKB:A0A8M3AV53 InterPro	1313
UniProtKB:A0A8M3B354 InterPro	1321
UniProtKB:A0A8N7TBM6 InterPro	1326
UniProtKB:A0A8M3AJU1 InterPro	1325
UniProtKB:A0A8M3AJU4 InterPro	1288
UniProtKB:A0A8M3AS70 InterPro	1302
UniProtKB:A0A8M3AKM9 InterPro	1314
UniProtKB:A0A8M2B661 InterPro	761
UniProtKB:A0A8M9PMQ4 InterPro	1307
UniProtKB:A0A8M3B358 InterPro	1034

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cngb1a-201 (1) Ensembl	Ensembl		1,837 nt	Select Tool ZFIN BLAST
mRNA	cngb1a-202 (1) Ensembl	Ensembl		2,469 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations