Gene
frmd4a
- ID
- ZDB-GENE-050419-154
- Name
- FERM domain containing 4A
- Symbol
- frmd4a Nomenclature History
- Previous Names
-
- si:ch211-220f12.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4A (FERM domain containing 4A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa666 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa7451 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa36573 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43047 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-frmd4a | LaCoursiere et al., 2024 | |
| CRISPR2-frmd4a | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia | 616819 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | Cytohesin Ubiquitin Protein Inducing Domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM domain-containing protein 4A/B | FERM, N-terminal | FERM superfamily, second domain | FRMD4A/B, FERM domain C-lobe | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AKA6 | InterPro | 1033 | |||||||||||||
| UniProtKB:A0A8M3ARU6 | InterPro | 1018 | |||||||||||||
| UniProtKB:A0A8M3ARU4 | InterPro | 1050 | |||||||||||||
| UniProtKB:A0A8M6YVZ2 | InterPro | 1048 | |||||||||||||
| UniProtKB:A0A8M3AKA2 | InterPro | 1064 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
frmd4a-201
(1)
|
Ensembl | 3,012 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-31J5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-220F12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128535 (1) | 3012 nt | ||
| Genomic | RefSeq:NW_018395004 (1) | |||
| Polypeptide | UniProtKB:A0A8M3AJF7 (1) | 1065 aa |
- Comparative Orthology
- Alliance
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Cowan, C.A., Hukriede, N.A., Handin, R.I., and Davidson, A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470(7332):95-100
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