Gene

frmd4a

ID

ZDB-GENE-050419-154

Name

FERM domain containing 4A

Symbol

frmd4a Nomenclature History

Previous Names

si:ch211-220f12.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4A (FERM domain containing 4A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frmd4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia	616819

Associated With frmd4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR021774	Cytohesin Ubiquitin Protein Inducing Domain
Domain	IPR041785	FRMD4A/B, FERM domain C-lobe
Family	IPR047176	FERM domain-containing protein 4A/B
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	Cytohesin Ubiquitin Protein Inducing Domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM domain-containing protein 4A/B	FERM, N-terminal	FERM superfamily, second domain	FRMD4A/B, FERM domain C-lobe	PH-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:A0A8M3AKA6 InterPro	1033
UniProtKB:A0A8M3ARU6 InterPro	1018
UniProtKB:A0A8M3ARU4 InterPro	1050
UniProtKB:A0A8M6YVZ2 InterPro	1048
UniProtKB:A0A8M3AKA2 InterPro	1064
UniProtKB:A2CGB3 InterPro	1003
UniProtKB:A0A8M3AJG1 InterPro	1049
UniProtKB:A0A8M3AUS0 InterPro	1051
UniProtKB:A0A8M3AJF7 InterPro	1065
UniProtKB:A0A8M3AUS4 InterPro	1029
UniProtKB:A0A8M3B2T1 InterPro	1040
UniProtKB:A0A8M3B2S7 InterPro	1064