Gene

meak7

ID
ZDB-GENE-050419-140
Name
MTOR associated protein, eak-7 homolog
Symbol
meak7 Nomenclature History
Previous Names
  • si:ch211-260p9.6
  • tldc1
  • zgc:153621
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be located in lysosomal membrane. Orthologous to human MEAK7 (MTOR associated protein, eak-7 homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Chiang et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With meak7 Human Ortholog
No data available
Associated With meak7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR006571 TLDc domain
Domain IPR035023 PLC-gamma, C-terminal SH2 domain
Domain IPR035024 PLC-gamma, N-terminal SH2 domain
Domain IPR035723 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
Family IPR001192 Phosphoinositide phospholipase C family
Family IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain C2 domain C2 domain superfamily EF-hand domain pair PH-like domain superfamily Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phospholipase C, phosphatidylinositol-specific, Y domain PLC-gamma, C-terminal SH2 domain PLC-gamma, N-terminal SH2 domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily Pleckstrin homology domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily TLDc domain
UniProtKB:Q1LWV8
InterPro
1240
UniProtKB:Q1LWV7
InterPro
450
UniProtKB:A0A8M9P137
InterPro
450
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tldc1-201 (1)
Ensembl
Ensembl 1,403 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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