Gene
sar1ab
- ID
- ZDB-GENE-050417-437
- Name
- secretion associated, Ras related GTPase 1Ab
- Symbol
- sar1ab Nomenclature History
- Previous Names
-
- sar1a
- fd13d02
- wu:fd13d02 (1)
- zgc:110650
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; regulation of COPII vesicle coating; and vesicle organization. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi cisterna membrane; endoplasmic reticulum; and lysosomal membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Levic et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42219 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase superfamily, ARF/SAR type | Small GTPase superfamily, SAR1-type | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q567Y5 | InterPro | 198 | ||||
| UniProtKB:B7ZD40 | InterPro | 198 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sar1ab-201
(1)
|
Ensembl | 1,658 nt | ||
| mRNA |
sar1ab-202
(1)
|
Ensembl | 876 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-26A17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-115D2 | ZFIN Curated Data | |
| Contains | SNP | rs3728556 | ZFIN Curated Data | |
| Encodes | EST | fd13d02 | ||
| Encodes | cDNA | MGC:110650 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192995 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017882 (1) | 1666 nt | ||
| Genomic | GenBank:AL929344 (1) | 190898 nt | ||
| Polypeptide | UniProtKB:B7ZD40 (1) | 198 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Levic, D.S., Minkel, J., Wang, W., Rybski, W.M., Melville, D.B., Knapik, E.W. (2015) Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. Journal of molecular medicine (Berlin, Germany). 93(2):165-176
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 4 of 4
Show